Juan F. Medrano
Department of Animal Science, UC Davis

 

Dairy Milk Components

  1. Medrano, J.F., and E. Aguilar-Cordova.  1990.  Genotyping of bovine kappa-casein loci following DNA sequence amplification.  Bio/Technology.  8:144-146.

  2. Medrano, J.F.  1990.  Application of the polymerase chain reaction procedure for genetic evaluation in cattle.  Proc. 4th World Congress on Genetics Applied to Livestock Production.  Edinburgh, July 23-27.  XIII:71-74.

  3. Medrano, J.F., and E. Aguilar-Cordova.  1990.  Polymerase chain reaction amplification of bovine ß-lactoglobulin genomic sequences and identification of genetic variants by RFLP analysis.  Animal Biotechnology  1:73-77

  4. Van Eenennaam, A.L., and J.F. Medrano.  1991.  Differences in allelic protein expression in the milk of heterozygous kappa-casein cows.  Journal of Dairy Science 74:1491-1496.

  5. Van Eenennaam, A.L., and J.F. Medrano.  1991.  Milk protein polymorphisms in the California dairy cattle population.  Journal of Dairy Science  74:1730-1742.

  6. Hollar, C.M., A.J.R. Law, D.G. Dalgleish, J.F. Medrano and R.J. Brown.  1992.  Separation of ß-casein A1, A2 and B using cation-exchange fast protein liquid chromatography.  Journal of Dairy Science 74:3308-3313.

  7. Medrano, J.F. 1992.  Biotecnologia en produccion animal: Mejoramiento de la calidad de la leche  (Biotechnology in animal production:  Improvement of the quality of milk).  Mundo Ganadero 3(12):25-30. 

  8. Ron, M., O. Yoffe, E. Ezra, J.F. Medrano and J.I. Weller. 1994.  Determination of milk protein genotype effects on production traits of Israeli Holsteins.  Journal of Dairy Science 77:1106-1113.   (In Press at Merit 7/94) 

  9. Famula, T.R., and J.F. Medrano.  1994.  Estimation of milk protein genotype effects with animal and sire transmitting ability models.  Journal of Dairy Science 77:3153-3162.  

  10. Tong, P.S., S. Vink, N.Y. Farkye, and J.F. Medrano.  1994.  Effect of genetic variants of milk proteins on the yield of Cheddar cheese. Proc. International Dairy Federation on Cheese Yield and Factors Affecting its Control, pp. 179-187; April 19-21, 1993; Cork, Ireland.  

  11. DePeters, E., J.F. Medrano and B.A. Reed.  1995.  Fatty acid composition of milk fat from three breeds of dairy cattle.  Can. Journal of Animal Science 75:267-269. 

  12. Gutierrez, A., H.M. Meade, Paul DiTullio, Daniel Pollock, Merry Harvey, R Jimenez-Flores, G.B. Anderson, J.D. Murray and J.F. Medrano.  1996. Expression  of a bovine k-Cn cDNA in the mammary gland of transgenic mice utilizing a genomic milk protein gene as an expression cassette.  Transgenic Research 5:271-279. 

  13. Gutierrez, A., E. Maga, C. Shoemaker, H.M. Meade, G.B. Anderson, J.F. Medrano, J.D. Murray.  1996.  Alterations of the physical characteristics of milk from transgenic mice producing bovine kappa-casein.  Journal of Dairy Science 79:791-799.

  14. Dovc, P., L. Lum and J.F. Medrano. 1996.  Differential allelic expression of lactoproteins: a model to study transcriptional regulation. Archiv/European Journal for Physiology 431:R203-R204.

  15. Lum, L.S., P.  Dovc and J.F. Medrano.  1997.  Polymorphisms of bovine beta-lactoglobulin promoter and differences in the binding affinity of activator protein-2 transcription factor. Journal of Dairy Sci.  80:1389-1397.

  16. Ojala, M., T. Famula and J.F. Medrano.  1997.  Effects of milk protein genotypes on the variation for milk production traits in California Holsteins and Jersey cows. J. Dairy Sci. 80:1776-1785.

  17. Folch, JM, P Dovc and JF Medrano. 1999. Differential expression of bovine b-lactoglobulin A and B promoter variants in transiently transfected HC11 cells. J. Dairy Research 66:537-544.

  18. Persuy MA, Printz C, Medrano JF, Mercier JC.  1999. A single nucleotide deletion resulting in a premature stop codon is associated with marked reduction of transcripts from a goat beta-casein null allele. Anim Genet. 30(6):444-51.

  19. Debeljak M, Susnik S, Marinsek-Logar R, Medrano JF, Dovc P.  2000. Allelic differences in bovine kappa-CN gene which may regulate gene expression. Pflugers Arch.;439(3 Suppl):R4-6

  20. Mistry D, DePeters EJ, Medrano JF.  2002.  Comparative composition of total and sn-2 fatty acids in bovine and ovine milk fat.  Dairy Sci. Tech.;82(2). (In press)

  21. Mistry, D., E.J. DePeters and J.F. Medrano 2002. Comparative Composition of Total and sn-2 Fatty Acids in Bovine and Ovine Milk Fat Le Lait Dairy Science and Technology 82:255-259.

  22. Mistry, D. and J.F.Medrano 2002. Cloning of the Bovine and the Sheep Lysophosphatidic Acid Acyltransferase (LPAAT). J. Dairy Science 85:28-35.

  23. Rincon, G. and J.F. Medrano 2003. Single nucleotide polymorphism (SNP) genotyping of bovine milk protein genes using the tetra primer ARMS-PCR. Animal Breeding and Genetics 120:1-9.  

  24. Suchyta, S.P S. Sipkovsky, R.Kruska, A. Jeffers, A. McNulty,.R.J. Tempelman, R.G. Halgren, P.M. Saama, D.E. Bauman, Y.R.Boisclair, J.L. Burton, R.J. Collier, E.J. DePeters, T.A. Ferris, M.C. Lucy, M.A. McGuire, J.F. Medrano, T.R. Overton, T.P. Smith, G.W. Smith, T. S. Sonstegard, J.N. Spain, D.E. Spiers, J.Yao and P.M. Coussens 2003. Development and testing of a high density cDNA microarray resource  for cattle. Physiological Genomics 15:158-164.

  25. Morimoto, K.C., A.L. Van Eenennaam, E.J. DePeters and J.F. Medrano 2005. Hot Topics: Endogenous Production of Omega-3 and Omega-6 Fatty Acids in Mammalian Cells. Journal of Dairy Science. 88:1142-1146. [Full Text]

 

Mouse 

  1. Medrano, J.F., D. Pomp, L. Sharrow, G.E. Bradford, T. Downs and L. Frohman.  1991.  Growth-hormone and IGF-I measurements in high growth mice.  Genetical Research 58:67-74.

  2. Horvat, S., and J.F. Medrano.  1994.   Targeting a specific genomic interval to identify RAPD markers linked to the high growth (hg) locus in mice.  Proceedings:  5th World Congress on Genetics Applied to Livestock Production.  21:71-74.

  3. Summers, P., and J.F. Medrano.  1994.  Morphometric analysis of skeletal muscle growth in the high growth mouse.   Growth, Devel & Aging 58(3): 135-148.

  4. Horvat, S., and J.F. Medrano.  1995.  Interval mapping of high growth (hg), a major locus that increases weight gain in mice.  Genetics 139:1737-1748. 

  5. Horvat, S., and J.F. Medrano.  1996.  Fine genetic mapping of the region surrounding the high growth (hg) locus in mouse chromosome 10: targeting random amplified polymorphic DNA (RAPD) markers. Mammalian Genome 7:312-314.

  6. Horvat, S., and J.F. Medrano.  1996.  The high growth (hg) locus maps to a deletion in mouse chromosome 10.  Genomics 36:546-549.

  7. Reiser, K., P. Summers, J.F. Medrano, R. Rucker, J. Last and R. McDonald. 1996.  The effects of elevated circulating IGF-1 on the extracellular matrix in high growth C57BL/6J mice.  American Journal of Physiology-Regulatory Integrative and Comparative Physiology 40:R690-703.

  8. Summers, P., and J.F. Medrano.  1997.  Delayed myogenesis associated with muscle fiber hyperplasia in high growth mice. Journal of Experimental Biology and Medicine 214 :380-385.

  9. Horvat, S. and J.F. Medrano  1998.  A 550-kb YAC and BAC contig encompassing the high growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region.  Genomics 54:159-164.

  10. Cargill, S.L. J.F. Medrano and G.B. Anderson. 1999.  Infertility in a Line of Mice with the high growth Mutation Is Due to Luteal Insufficiency Resulting from Disruption at the Hypothalamic-Pituitary Axis. Biol. Reprod. 61:283-287.

  11. Corva, P.M., S. Horvat and J.F. Medrano 2001. Quantitative trait loci affecting growth in high growth (hg) mice. Mammalian Genome 12(4):284-290.

  12. Corva, P.M. and J.F. Medrano 2001. Quantitative Trait Loci (QTL) mapping for growth in the mouse: A review Genetic Selection and Evolution 2: (in press)

  13. Corva,  P.M. and J. F. Medrano  2000.  Diet effects on weight gain and body composition in high growth (hg/hg) mice.  Physiological Genomics  3:17-23. 

  14. Smith J, I.R. Paton, S. Horvat, J.F. Medrano, D.W. Burt  2000. Mapping the RAIDD gene of chicken (Gallus gallus): identification of a region homologous to the mouse high-growth region. Mamm Genome 11(8):706-709.

  15. Cargill, S.L., G.B. Anderson, T.R. Famula and J.F. Medrano. 2000.  Effectc of the high growth (hg) locus on reproductive functions in High Growth (HG) females mice. Growth Dev Aging 64:21-31.

  16. Horvat, S. and J.F. Medrano 2001. Lack of Socs2 expression causes the high growth phenotype in mice. Genomics 72:209-212.  

  17. Corva, P.M., J.F. Medrano.  2001.  Quantitative trait loci (QTL) mapping for growth in the mouse: A review.  Genetic Selection and Evolution 33:105-132.

  18. Bunger, L., E. Bradford, J.F. Medrano, G. Eisen.  2001.  Inbred lines of mice derived from long-term on growth selected lines: unique resources for mapping growth genes.  Mammalian Genome 12:679-686.

  19. Wong, M.J., A.D. Islas-Trejo and J.F. Medrano 2002.  Structural characterization of the mouse High Growth deletion and discovery of a novel fusion transcript between suppressor of cytokine signaling-2 (Socs-2) and viral encoded semaphoring receptor (Plexin C1). Gene 299:153-163.

  20. Complex Trait Consortium (CTC) 2003.  The nature and identification of quantitative trait loci: a community’s view.  Nature Reviews 4:911-916.

  21. Warden, C.H., S. Stone, S. Chiu, A.L. Diament, D. Shattuck, R.Riley, P.Corva, J.Easlick, J.S. Fisler and J.F. Medrano  2004. Identification of a congenic mouse line with obesity and body length phenotypes. Mamm Genome 15:460-71.

  22. Corva, P.M., N.C. Mucci, K. Evans and J.F. Medrano 2004. Diet effects on reproduction in high growth (hg/hg)  female mice that are deficient in the Socs-2 gene. Reproduction, Nutrition, Development 44:303-312.  

  23. Complex Trait Consortium (CTC) 2004.  The Collaborative Cross, a community resource for the genetic analysis of complex traits nature Genetics 36:1133 – 1137.  

  24. Wu,  R., C. Ma, W. Hou, P. Corva and J.F Medrano 2005. Functional Mapping of Quantitative Trait Loci That Interact With the hg Mutation to Regulate Growth Trajectories in Mice. Genetics 17:239-249. [Full text]

  25. Wong, M.I. and J.F. Medrano 2005.  A Primer on Real Time PCR for mRNA Quantitation. (Review). BioTechniques 39:75-85.

  26. Verdugo, R. A. and J. F. Medrano 2006. Comparison of gene coverage of mouse oligonucleotide microarray platforms. BMC Genomics 7: 58. [Full text]

  27. Farber, C. R., P.M. Corva and J.F. Medrano 2006. Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains. BMC Genomics 7(1):102. [Full text]
     

Sheep

  1. Medrano, J.F., and A. Loarca.  1978.  Sheep production potential in the Guatemalan Highlands.  Presented at the Conference on the Interaction of Agriculture, Science and Food Technology and Nutrition, Guatemala (INCAP), November.  

  2. Cushwa, W.T., and J.F. Medrano.  1994.  Identification of RAPD genetic markers in sheep.  Proceedings:  5th World Congress on Genetics Applied to Livestock Production.  21:133-136. 

  3. Cargill, S.H., G.B. Anderson and J.F. Medrano. 1995. Development of a species-specific marker using RAPD analysis to distinguish between sheep and goat.  Animal Biotechnology 6:93-100. 

  4. Cushwa, W., and J.F. Medrano.  1996.  Applications of the random amplified polymorphic DNA (RAPD) assay for genetic analysis of livestock species. Animal Biotechnology 7:11-31.

  5. Cockett, N.E., and J.F. Medrano. 1996.  Use of the sheep genome map. Beltsville Symposium in Agricultural Research XX: Biotechnology’s Role in the Genetic Improvement of Farm Animals.  Editors: R.H. Miller, V.G. Pursel, and H.D. Norman.  Published by the American Society of Animal Science, Savoy, IL., pp. 81-90.

  6. Cushwa, W., K.G. Dodds, A.M. Crawford and J.F. Medrano 1996. Identification and genetic mapping of random amplified polymorphic DNA (RAPD) markers to the sheep genome.  Mammalian Genome 7:580-585.

  7.  Maddox J.F., Davies K.P., Crawford A.M., Hulme D.J., Vaiman D., Cribiu E.P., Freking B.A., Beh K.J., Cockett N.E., Kang N., Riffkin C.D., Drinkwater R., Moore S.S., Dodds K.G., Lumsden J.M., van Stijn T.C. , Phua S.H., Adelson D.L., Burkin H.R., Broom J.E., Buitkamp J., Cambridge L., Cushwa W.T., Gerard E., Galloway S.M., Harrison B., Hawken R.J., Hiendleder S., Henry H.M., Medrano J.F., Paterson K.A., Schibler L., Stone R.T., van Hest B. 2001.  An enhanced linkage map of the sheep genome comprising more than 1000 loci. Genome Research 11:1275-1289.

 

Fish

  1. Moore, B.J., S.S.O. Hung and J.F. Medrano.  1988. Protein requirement of hatchery-produced juvenile white sturgeon (Acipenser transmontanus).  Aquaculture 71:235-245.

  2. Ferreiro, C., J.F. Medrano and G.A.E. Gall.  1989.  Genome analysis of rainbow trout and sturgeon with restriction enzymes and hybridization with a ZFY gene derived probe to identify sex.  Aquaculture  81:245-251.

  3. Van Eenennaam, A., J.P. Van Eenennaam, J.F. Medrano and S.  Doroshov.  1996.  Rapid verification of meiotic gynogenesis and polyploidy in white sturgeon (Acipenser transmontanus Richardson).  Aquaculture 147:177-189.

  4. Bagley, M.J., J.F. Medrano and G.A.E. Gall 1997. Polymorphic molecular markers from anonymous nuclear DNA for genetic analysis of populations. Molecular Ecology 6:309-320.

  5. Van Eenennaam, A.L., J.D. Murray, and J.F. Medrano. 1998. Synaptonemal complex analysis in spermatocytes of white sturgeon, Acipenser transmontanus Richardson (Pisces, Acipenseridae), a fish with a very high chromosome number. Genome 41:51-61.

  6. Van Eenennaam, A.L., J.D. Murray and J.F. Medrano. 1998. Mitotic analysis of the North American white sturgeon, Acipenser transmontanus Richardson (Pisces, Acipenseridae), a fish with a very high chromosome number. Genome 41:266-271.

  7. Iturra, P., J.F. Medrano, M. Bagley, N. Lam, N. Vergara and J.C. Marin 1998.  Identification of sex chromosome molecular markers using RAPDs and fluorecent in situ hybridization in rainbow trout.  Genetica Vol. 101(3):209-213.

  8. Van Eenennaam, A.L., Van Eenennaam, J.F., Medrano and Doroshov, S.I. 1999. Evidence of  female heterogametic genetic sex determination in sturgeon.  Journal of Heredity 90:231-233.

  9. Van Eenennaam, A. L., J. D. Murray, and J. F. Medrano.1999. Karyotype of the American green sturgeon. Transactions of the American Fisheries Society 128: 175-177.

  10. Iturra, P., J.F. Medrano, M. Bagley, N. Vergara and P. Imbert  2001. Development and characterization of  DNA sequence Omy P9 associated with the sex chromosomes in rainbow trout.  Heredity 86:412-419.

 

Tribolium castaneum

  1. Medrano, J.F., and G.A.E. Gall.  1976.  Growth rate, body composition, cellular growth and enzyme activities in lines of Tribolium castaneum selected for 21‑day pupa weight.  Genetics 83:379-391.

  2. Medrano, J.F., and G.A.E. Gall.  1976.  Food consumption, feed efficiency, metabolic rate and utilization of glucose in lines of Tribolium castaneum selected for 21-day pupa weight.  Genetics 83:393-407.

  3. Medrano, J.F., R. Gomez, L.G. Elias and R. Bressani. 1976.  Uso de gorgojos para evaluar el valor nutritivo de las proteinas.  Rev. C. A. de Nutrition y Ciencia de Alimentos 1:3-4. 

  4. Medrano, J.F., and G.A.E. Gall.  1976.  Direct and correlated responses to selection for body size and oxygen consumption in Tribolium.  Journal of Animal Science 43:739-754.  

  5. Medrano, J.F., and R. Bressani.  1977.  Evaluation of nutritional quality of food with the red flour beetle (Tribolium castaneum).  I.  Effect of protein concentration in the diet on larval growth, and developmental time.  Nutrition Reports International 16:255-266.  

  6. Medrano, J.F., R. Bressani, R. Gomez‑Brenes and L.G. Elias.  1979.  Evaluation of nutritional quality of food with the red flour beetle (Tribolium castaneum).  II.  Evaluation of corn, wheat and a processed soybean:corn preparation.  Nutrition Reports International 20:11-24. 

Other Molecular Projects and Cattle

  1. Farber, C.R. and J. F. Medrano 2003. In silico anchoring of ESTs, genes and genomic sequence to bovine, porcine and chicken genome maps using SSLP markers. Animal Genetics 34:11-18.

  2. Anderle, P., M. Duval, S. Draghici, A. Kuklin, T. G. Littlejohn, J. F. Medrano, D. Vilanova, and M. A. Roberts. 2003.  Gene Expression Databases and Data Mining. In: Microarrays and Cancer: Research and Applications. Guest Editors Michael F. Ochs and Andrew K. Godwin.  BioTechniques 34: S36-S44.

  3. Rossier, O., J. Cao, T. Huque, A.I. Spielman, R.S. Feldman, J. F. Medrano, J.G. Brand and J. le Coutre  2004. Analysis of a Human Fungiform Papillae cDNA Library and Identification of Taste-related Genes. Chemical Senses 29:13-23.

  4. Farber, C.R. and J.F. Medrano 2004. Identification of putative homology between horse microsatellite flanking sequences and cross-species ESTs, mRNAs and genomic sequences. Animal Genetics 35:28-33.

  5. Rincon, G. and J. F. Medrano 2006. Assays for genotyping single nucleotide polymorphisms in the bovine CAPN1 gene. Anim Genet 37(3): 294-5. [Abstract]

     

     

     

 

 

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