A major portion of our research effort uses systems analysis and modeling
in support of our research in biochemistry and metabolism, with special
interest in integration and synthesis of animal metabolism. Current research
efforts focus on protein and energy metabolism in animals and birds with
limited work with fish and reptiles. The efforts in protein metabolism are
directed towards identification of body amino acid pools used for protein
synthesis. This work has led to the development of a mechanistic
mathematical model of protein turnover.
A second area of research examines the putative role that cellular
hydrogen ion concentration has upon metabolism and carbon flux through
metabolic pathways. Current research in this area uses the lysine-arginine
antagonism as a model to study the impact of altering hydrogen ion
concentration on metabolism. This research as also demonstrated that a
single amino acid, lysine, can alter the concentration the mRNA for renal
arginase.
The third area of research interest relates to the nutrient requirements
of captive animals. We are involved in work with metabolism and nutrient
requirements of captive animals. A principle focus examines how an immune
response to a disease challenge may influence nutrient needs, growth,
reproduction and well-being of birds, and the impact of nutrition on
immunity and disease resistance. Current research examines the impact of
stress on glucose and cationic amino acid transport systems.
