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Hong Chang
Graduate Student, Ph.D.
Genetics (GGG)
Major Professor: Mary E. Delany
Phone: (530)754 - 9404
FAX: (530)752-0175
Email: hgchang@ucdavis.edu
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Education
B.S., Biotechnology, Northeast Agricultural University, China, 1997
M.S., Basic veterinary medicine, Northeast Agricultural University,
China, 2001
Ph.D., Genetics, University of California, Davis (In Progress)
Research topic: Avian chromosome biology: Genome organization and function
- Currently, scientists have successfully constructed yeast artificial
chromosomes, bacterial artificial chromosomes, phage artificial chromosomes
and mammalian artificial chromosomes, which have been used in many
biological fields of study. The artificial chromosome has become an
important tool to detect the functions and characteristics of telomere,
centromere and replication origin of chromosomes, to determine the essential
elements controlling chromosome performance during mitosis and miosis, and
to artificially modify the existing chromosomes to obtain transgenic
animals. The artificial chromosome also has potential as gene delivery
vectors for gene therapy.
My present research work is to construct chicken artificial chromosomes
by using avian leucosis virus (ALV)-induced chicken bursal cell line DT40.
The remarkable property of DT40 cells is that they show high ratios of
targeted to random integration after DNA transfection. This means that the
function of genes involved in chicken cells can be easily studied by
knockouts and other related artificial chromosome techniques. Research using
chicken artificial chromosomes would facilitate our understanding of chicken
chromosome biology, genome organization and manipulation.
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