Fish Nutrition and Toxicology Group
Department of Animal Science 

UC Davis - The University of California, Davis

Silas S.O. Hung.
 

Anne Marie Bakke-McKellep

Leirfivelveien 76
1346 Gjettum
Norway
Phone +47 22 96 45 59
Mobile +47 993 59 262
E-mail: anne.mckellep@veths.no

Education

  • 1999 Dr.med.vet. (Ph.D.) in Animal Nutrition, Norwegian School of Veterinary Science, Oslo, Norway
  • 1993 Med.vet. (DVM equivalent), Ludwig-Maximilians-Universität München, Munich, Germany
  • 1986 B.S. cum laude in Animal Science, University of Connecticut, Storrs, CT, USA

Current Position

Research scientist (Research Council of Norway-funded), Norwegian School of Veterinary Science.

Professional Experience

  • 2004- Research scientist, Norwegian School of Veterinary Science
  • 2004-2005 Visiting Fulbright Scholar, Department of Animal Science, University of California, Davis
  • 1999-2003 Postdoctoral fellowship, Norwegian School of Veterinary Science
  • 1994-1999 Research fellowship in Animal Nutrition, Norwegian School of Veterinary Science
  • 1993-1994 Veterinary clinical practice, Finnsnes (District vet. Kjell Nyberg) and Åndalsnes (District vet. Nils Hydle), Norway
  • 1990-1992 Harrison Clinical Research GmbH, Munich, Germany. Language consultant and report compilation of clinical trials for different pharmacological products; part-time work during veterinary studies.
  • 1986-1987 Section for Biochemistry, Department of Anatomy, Physiology and Hygiene of Domestic Animals, University of Bonn, Germany. Internship.

Areas of Research

Morphology and function of the gastrointestinal tract and other organs of cultured fish species fed novel feed ingredients, including genetically modified; pathophysiological and immunological effects of soybean meal-induced enteritis in salmonids; in vitro intestinal absorption of nutrients in fish; transport and distribution of dietary lipid; anti-nutritional factors; digestive disturbances in cultured fish.

Professional Societies

Norwegian Association of Research Workers
Norwegian Veterinary Association 1993-2006

Honours and Awards

Fulbright Research Scholar to USA, 2004-2005

Funded Research Project Affiliation

  • Research Council of Norway: Strategic program “Traceability and physiological effects of using genetically modified plant products in feed for Atlantic salmon” (Grant nr. 142474/140), 2001-2005
  • Research Council of Norway: Center of Excellence “Aquaculture Protein Centre” (APC; Grant nr. 145949/120), 2003-2012
  • Research Council of Norway: “Genetically modified plant products (GMPP) in feed for Atlantic salmon – A follow-up study on physiological responses and DNA traceability” (Grant nr. 172151/S40), 2006-2009.

Publications

  • Proceedings and book chapters since 1997: 1 published; 1 in press
  • Other conference presentations since 1997 (abstracts and proceedings): >20
  • Number of reports since 1997: 1
  • Number of reviews since 1997: 1
  • Number of popular science publications since 1997: 1
  • Number of articles since 1997: 25
  • Total number of scientific papers (peer reviewed): 26


Papers, published and in press in peer reviewed journals 1997-2007

  • Bakke-McKellep AM, Sanden M, Danieli A, Acierno R, Hemre G-I, Maffia M, Krogdahl Å (2008) Atlantic salmon (Salmo salar L.) parr fed genetically modified soybeans and maize: histological, digestive, metabolic, and immunological investigations. Research in Veterinary Science 84, 395-408.
  • Bakke-McKellep AM, Frøystad M, Lilleeng E, Dapra F, Refstie S, Krogdahl Å, Landsverk T (2007) Response to soy: T-cell-like reactivity in the intestine of Atlantic salmon, Salmo salar L. Journal of Fish Diseases 30, 13-25.
  • Aas TS, Hatlen B, Grisdale-Helland B, Terjesen BF, Penn M, Bakke-McKellep AM, Helland SJ (2007) Feed intake, growth and nutrient utilization in Atlantic halibut (Hippoglossus hippoglossus) fed diets containing a bacterial protein meal. Aquaculture Research 38, 351-360.
  • Bakke-McKellep AM, Penn MH, Salas PM, Refstie S, Sperstad S, Landsverk T, Ringø E, Krogdahl Å (2007) Effects of dietary soyabean meal, inulin and oxytetracycline on intestinal microbiota and epithelial cell stress, apoptosis and proliferation in the teleost Atlantic salmon (Salmo salar L.). British Journal of Nutrition 97, 699-713.
  • Hemre, G-I, Sagstad A, Bakke-McKellep AM, Danieli A, Acierno R, Maffia M, Frøystad M, Krogdahl Å, Sanden M (2007) Nutritional, physiological, and histological responses in Atlantic salmon, Salmo salar L. fed diets with genetically modified maize. Aquaculture Nutrition 13, 186-199.
  • Bakke-McKellep AM, Koppang EO, Gunnes G, Sanden M, Hemre G-I, Landsverk T, Krogdahl Å (2007) Histological, digestive, metabolic, hormonal and some immune factor responses in Atlantic salmon, Salmo salar L., fed genetically modified soybeans. Journal of Fish Diseases 30, 65-79.
  • Bakke-McKellep AM, Refstie S, Stefansson SO, Vanthanouvong V, Roomans G, Hemre G-I, Krogdahl Å (2006) Effects of dietary soybean meal and photoperiod cycle on osmoregulation following seawater exposure in Atlantic salmon (Salmo salar L.) smolt. Journal of Fish Biology 69, 1396-1426.
  • Refstie S, Landsverk T, Bakke-McKellep AM, Ringø E, Sundby A, Shearer KD, Krogdahl Å (2006) Digestive capacity, intestinal morphology, and microflora of 1-year and 2-year old Atlantic cod (Gadus morhua) fed standard or bioprocessed soybean meal. Aquaculture 261, 269-284.
  • Aas TS, Hatlen B, Grisdale-Helland B, Terjesen BF, Bakke-McKellep AM, Helland SJ (2006) Effects of diets containing a bacterial protein meal on growth and feed utilisation in rainbow trout (Oncorhynchus mykiss). Aquaculture 261, 357-368.
  • Refstie S, Bakke-McKellep AM, Penn MH, Sundby A, Shearer KD, Krogdahl Å (2006) Capacity for digestive hydrolysis and amino acid absorption in Atlantic salmon (Salmo salar) fed diets with soybean meal or inulin with or without addition of antibiotics. Aquaculture 261, 392-406.
  • Sanden M, Krogdahl Å, Bakke-McKellep AM, Buddington RK, Hemre G-I (2006) Growth performance and organ development in Atlantic salmon, Salmo salar L. parr fed genetically modified (GM) soybean and maize. Aquaculture Nutrition 12, 1-14.
    Bakke-McKellep AM, Krogdahl Å (2005) Letter to the editor of Aquaculture. Aquaculture 250 (3-4),541.
  • Krogdahl Å, Bakke-McKellep AM (2005) Fasting and refeeding cause rapid changes in intestinal tissue mass and digestive enzyme capacities of Atlantic salmon (Salmo salar L.). Comparative Biochemistry and Physiology A 141, 450-460.
  • Nielsen CN, Berdal KG, Bakke-McKellep AM, Holst-Jensen A (2005). Dietary DNA in blood and liver of Atlantic salmon (Salmo salar L.). European Food Research and Technology 221: 1-8.
  • Sanden M, Berntssen MHG, Krogdahl A, Hemre G-I, Bakke-McKellep AM (2005) An examination of the intestinal tract of Atlantic salmon (Salmo salar L.) parr fed different varieties of soy and maize. Journal of Fish Diseases 28, 317-330.
  • Hemre G-I, Sanden M, Bakke-McKellep AM, Sagstad A, Krogdahl A (2005) Growth, feed utilization and health of Atlantic salmon Salmo salar L. fed genetically modified compared to non-modified commercial hybrid soybeans. Aquaculture Nutrition 11, 157-168.
  • Sigurdardottir OG, Bakke-McKellep AM, Djonne B, Evensen O (2005) Mycobacterium avium subsp. paratuberculosis enters the small intestinal mucosa of goat kids in areas with and without Peyer's patches as demonstrated with the everted sleeve method. Comparative Immunology, Microbiology & Infectious Diseases 28, 223-230.
  • Denstadli V, Vegusdal A, Krogdahl A, Bakke-McKellep AM, Berge GM, Holm H, Hillestad M, Ruyter B (2004) Lipid absorption in different segments of the gastrointestinal tract of Atlantic salmon (Salmo salar L). Aquaculture 240, 385-398.
  • Krogdahl A, Bakke-McKellep AM, Baeverfjord G (2003) Effects of graded levels of standard soybean meal on intestinal structure, mucosal enzyme activities, and pancreatic response in Atlantic salmon (Salmo salar L.). Aquaculture Nutrition 9, 361-371.
  • Meltzer HM, Haugen M, Haavardsholm KC, Hagen KB, Heier HE, Bakke-McKellep AM, Glorstad H, Tandberg A (2002) Blodtypedietten - visjonær vitenskap eller tull? (The blood-type diet - visionary science or nonsense?). Tidsskrift for Den norske lægeforening (J Norw Med Assoc) 122, 1402-1405.
  • Krogdahl A, Bakke-McKellep AM, Røed KH, Bæverfjord G (2000) Feeding Atlantic salmon (Salmo salar L.) soybean products: Effects on disease resistance (furunculosis), and lysozyme and IgM levels in the intestinal mucosa. Aquaculture Nutrition 6, 77-84.
  • Bakke-McKellep AM, Press CM, Krogdahl A, Landsverk T (2000) Changes in immune and enzyme histochemical phenotypes of cells of the intestinal mucosa of Atlantic salmon (Salmo salar L.) with soybean-meal induced enteritis. Journal of Fish Diseases 23, 115-127.
  • Nordrum S, Bakke-McKellep AM, Krogdahl A, Buddington RK (2000) Effects of soybean meal and salinity on intestinal transport of nutrients in Atlantic salmon (Salmo salar L.) and rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology B 125, 317-335.
  • Bakke-McKellep AM, Nordrum S, Krogdahl A, Buddington RK (2000) Absorption of glucose, amino acids, and dipeptides by the intestines of Atlantic salmon (Salmo salar L.). Fish Physiology and Biochemistry 22, 33-44.
  • Berge GE, Bakke-McKellep AM, Lied E (1999) In vitro uptake and interaction between arginine and lysine in the intestine of Atlantic salmon (Salmo salar). Aquaculture 179, 181-193.
  • Buddington RK, Krogdahl A, Bakke-McKellep AM (1997) The intestines of carnivorous fish: structure and functions and the relations with diet. Acta Physiol Scand Suppl. 638, 67-80.

Ph.D. Thesis:

  • Bakke-McKellep AM, 1999. Intestinal nutrient absorption in Atlantic salmon (Salmo salar L.) and pathophysiological response of the intestinal mucosa to dietary soybean meal. Ph.D. thesis, Norwegian School of Veterinary Science, Oslo.

Book chapters:

  • Bakke-McKellep AM, Refstie S (2007) Alternative protein sources and digestive function alterations in teleost fishes. In Feeding and Digestive Functions of Fishes (eds. JEP Cyrino, R Roubach, D Bureau and BG Kapoor). Science Publishers Inc., Enfield NH, USA, in press 2007-06
  • Krogdahl Å, Bakke-McKellep AM (2004) Physiological mechanisms in the impairment of nutrient digestion and transport capacity in the salmon intestine by soybean antinutrients. In EAAP publication: Recent Advances of Research in Antinutritional Factors in Legume Seeds and Oilseeds (eds. M Muzquis, GD Hill, C Cuadrado, MM Pedrosa, C Burdano. Wageningen Academic Publ., Wageningen NL, pp. 111-114.