Chicken Genome Sequenced!
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Professor Mary
Delany admires a Red Jungle Fowl rooster,
the species studied to sequence the chicken genome. |
An analysis of the chicken genome was published as the cover story of
the December 9, 2004, issue of the prestigious international journal,
Nature. Associate Professor Mary Delany took the cover photo of a
newly hatched chick. Mary was one of 11 scientists who coordinated the
analysis, the collaborative work of the International Chicken Genome
Sequencing Consortium that involved dozens of people from 49
institutions and 13 countries. Mary’s expertise in avian biology was
essential to interpret the analysis. Her laboratory also determined
whether particular repeated sequences, specifically telomeres present at
the ends of chromosomes and ribosomal genes important for
growth, were correctly represented in the assembled sequence.
The chicken genome, the first to be sequenced from
any species of livestock or bird, has already yielded rich comparisons
with the genomes of humans, mice, rats and dogs. The chicken genome is
only a third as large as mammalian genomes. Similarities and differences
will help scientists understand how different types of DNA sequences
function.
DNA for the first chicken genome sequence came
from a female Red Jungle Fowl from the inbred UCD 001 line developed in
the late 1950s at UC Davis by Hans Abplanalp, Professor
Emeritus of Avian Sciences. The Red Jungle Fowl is the ancestor of all
domestic chickens. During the 1990s, UCD 001 birds were used to create
genomic resources that were essential when methods became available to
sequence entire genomes. This illustrates how conservation of avian
genetic stocks can support unforeseen research advances for this
important agricultural species and research model. The Department of
Avian Sciences, now Animal Science, has maintained endangered avian
genetic stocks as living collections, since avian eggs and embryos do
not survive freezing and thawing as is possible with mammals. The
department established the Avian Genetic Stocks Conservation Fund to
assist in this endeavor. Contributions may be made using the enclosed
insert and envelope.
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