Michael J. Mienaltowski
Michael J. Mienaltowski, DVM, Ph.D.
|Phone: +1 530-207-3226
FAX: +1 530-752-0175
B.S., Michigan State University, 1999 (Zoology: Cellular & Developmental Biology).
DVM., Michigan State University, 2004.
Ph.D., University of Kentucky, 2008 (Veterinary Science).
Post-doctoral training, University of South Florida, 2008-2014 (Molecular Pharmacology & Physiology; Orthopaedics & Sports Medicine).
My primary research interests are based in the development, maturation, and repair of musculoskeletal tissues. Past efforts have been focused on articular cartilage and tendon, particularly on how phenotypes for cells like chondrocytes, bone marrow stromal cells, and tendon peritenon- and tendon proper-derived progenitor cells differ by niche, or surrounding environment. Additionally, because collagen assembly and organization are important to functionally sound musculoskeletal tissue, my research interests include the examination of how collagen fibrillogenesis might be manipulated to achieve optimal recovery of tissues with repair. The ultimate goal is to determine if alterations in niche components and organization and/or interacting cell physiology can lead to alterations in repair pathways or tissue engineering strategies to prevent and treat musculoskeletal injury. In order to reach this goal, I rely on functional genomics as well as expressional (mRNA and protein) analyses, morphometric analyses, and biomechanical assays.
I am interested in the physiology of usage and elite performance as well as pathophysiology from over-usage, acute and chronic injury for all musculoskeletal tissues on all species, as they might be related to use, environment, or genetics. Though past efforts have been primarily in horse and mouse, all animals are subject to musculoskeletal injury. Moreover, from performance species like dogs, horses, and us humans, to production species like cattle, swine, and poultry, painful musculoskeletal injuries and disorders are both costly and debilitating on so many levels.